Colitis Following Initiation of Sofosbuvir and Simeprevir for Genotype 1 Hepatitis C.
- Author(s): Sarkar, Souvik
- Mitchell, Kisha A
- Lim, Joseph K
- Oikonomou, Ioannis
- Jakab, Simona
- et al.
Published Web Locationhttps://doi.org/10.14309/crj.2015.96
Sofosbuvir and simeprevir are used for the treatment of chronic hepatitis C (HCV) genotype 1. Both drugs have been well-tolerated, with diarrhea noted in 6% cases with sofosbuvir, 16% with sofosbuvir plus simeprevir, and 0% with simeprevir. No prior reports exist of colitis secondary to either drug or their combination. We report a patient with no prior history of inflammatory bowel disease who developed significant bloody diarrhea within 2 weeks of sofosbuvir/simeprevir initiation. Colonoscopy and biopsy confirmed pancolitis, which responded to mesalamine and completion of sofosbuvir/simeprevir.