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Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1+/- Mice

  • Author(s): Nakamura, Jean
  • Mroue, R
  • Huang, B
  • Braunstein, S
  • Firestone, AJ
  • Nakamura, JL
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4441450?pdf=render
No data is associated with this publication.
Abstract

© 2015 Mroue et al.Imprinted genes are expressed from only one parental allele and heterozygous loss involving the expressed allele is sufficient to produce complete loss of protein expression. Genetic alterations are common in tumorigenesis but the role o

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