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Optical coherence tomography of malignancy in hamster cheek pouches.

  • Author(s): Matheny, Erin S
  • Hanna, Nevine M
  • Jung, WG
  • Chen, Zhongping
  • Wilder-Smith, Petra
  • Mina-Araghi, Reza
  • Brenner, Matthew
  • et al.

Published Web Location

https://doi.org/10.1117/1.1783897Creative Commons 'BY' version 4.0 license
Abstract

Optical coherence tomography (OCT)/optical Doppler tomography (ODT) provides real-time in vivo high-resolution (10-microm) imaging of tissues and real-time spatially resolved blood flow in microvasculature. Hamster cheek pouches with induced dysplasia and malignancies were imaged with OCT/ODT to assess the potential for application to airway malignancy. In 22 Golden Syrian hamsters, 0.5% 9,10-dimethyl-1,2-benzanthracene induces carcinogenesis over 10 weeks in right side cheek pouches; the left side three served as controls. The cheek pouches are imaged in vivo prior to sacrifice, and in vitro after excision, using a prototype 1310-nm broadband superluminescent diode based OCT/ODT device. Images are compared to standard histopathology. OCT imaging offers good resolution of the hamster cheek pouches to depths of 1 to 3 mm and paralleled histologic images. The feasibility of high-resolution functional imaging is demonstrated in this hamster cheek pouch tumor model. ODT accurately detects vascular change associated with carcinogenesis.

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