Skip to main content
eScholarship
Open Access Publications from the University of California

UC Riverside

UC Riverside Previously Published Works bannerUC Riverside

Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules.

  • Author(s): Bakolitsa, Constantina;
  • Xu, Qingping;
  • Rife, Christopher L;
  • Abdubek, Polat;
  • Astakhova, Tamara;
  • Axelrod, Herbert L;
  • Carlton, Dennis;
  • Chen, Connie;
  • Chiu, Hsiu Ju;
  • Clayton, Thomas;
  • Das, Debanu;
  • Deller, Marc C;
  • Duan, Lian;
  • Ellrott, Kyle;
  • Farr, Carol L;
  • Feuerhelm, Julie;
  • Grant, Joanna C;
  • Grzechnik, Anna;
  • Han, Gye Won;
  • Jaroszewski, Lukasz;
  • Jin, Kevin K;
  • Klock, Heath E;
  • Knuth, Mark W;
  • Kozbial, Piotr;
  • Krishna, S Sri;
  • Kumar, Abhinav;
  • Lam, Winnie W;
  • Marciano, David;
  • McMullan, Daniel;
  • Miller, Mitchell D;
  • Morse, Andrew T;
  • Nigoghossian, Edward;
  • Nopakun, Amanda;
  • Okach, Linda;
  • Puckett, Christina;
  • Reyes, Ron;
  • Tien, Henry J;
  • Trame, Christine B;
  • van den Bedem, Henry;
  • Weekes, Dana;
  • Hodgson, Keith O;
  • Wooley, John;
  • Elsliger, Marc André;
  • Deacon, Ashley M;
  • Godzik, Adam;
  • Lesley, Scott A;
  • Wilson, Ian A
  • et al.
Abstract

The crystal structure of the Bacteroides thetaiotaomicron protein BT_3984 was determined to a resolution of 1.7 Å and was the first structure to be determined from the extensive SusD family of polysaccharide-binding proteins. SusD is an essential component of the sus operon that defines the paradigm for glycan utilization in dominant members of the human gut microbiota. Structural analysis of BT_3984 revealed an N-terminal region containing several tetratricopeptide repeats (TPRs), while the signature C-terminal region is less structured and contains extensive loop regions. Sequence and structure analysis of BT_3984 suggests the presence of binding interfaces for other proteins from the polysaccharide-utilization complex.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View