Skip to main content
eScholarship
Open Access Publications from the University of California

UC Riverside

UC Riverside Previously Published Works bannerUC Riverside

Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules.

  • Author(s): Bakolitsa, Constantina
  • Xu, Qingping
  • Rife, Christopher L
  • Abdubek, Polat
  • Astakhova, Tamara
  • Axelrod, Herbert L
  • Carlton, Dennis
  • Chen, Connie
  • Chiu, Hsiu Ju
  • Clayton, Thomas
  • Das, Debanu
  • Deller, Marc C
  • Duan, Lian
  • Ellrott, Kyle
  • Farr, Carol L
  • Feuerhelm, Julie
  • Grant, Joanna C
  • Grzechnik, Anna
  • Han, Gye Won
  • Jaroszewski, Lukasz
  • Jin, Kevin K
  • Klock, Heath E
  • Knuth, Mark W
  • Kozbial, Piotr
  • Krishna, S Sri
  • Kumar, Abhinav
  • Lam, Winnie W
  • Marciano, David
  • McMullan, Daniel
  • Miller, Mitchell D
  • Morse, Andrew T
  • Nigoghossian, Edward
  • Nopakun, Amanda
  • Okach, Linda
  • Puckett, Christina
  • Reyes, Ron
  • Tien, Henry J
  • Trame, Christine B
  • van den Bedem, Henry
  • Weekes, Dana
  • Hodgson, Keith O
  • Wooley, John
  • Elsliger, Marc André
  • Deacon, Ashley M
  • Godzik, Adam
  • Lesley, Scott A
  • Wilson, Ian A
  • et al.
Abstract

The crystal structure of the Bacteroides thetaiotaomicron protein BT_3984 was determined to a resolution of 1.7 Å and was the first structure to be determined from the extensive SusD family of polysaccharide-binding proteins. SusD is an essential component of the sus operon that defines the paradigm for glycan utilization in dominant members of the human gut microbiota. Structural analysis of BT_3984 revealed an N-terminal region containing several tetratricopeptide repeats (TPRs), while the signature C-terminal region is less structured and contains extensive loop regions. Sequence and structure analysis of BT_3984 suggests the presence of binding interfaces for other proteins from the polysaccharide-utilization complex.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View