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Calcium Channels in Vascular Smooth Muscle.

  • Author(s): Ghosh, D
  • Syed, AU
  • Prada, MP
  • Nystoriak, MA
  • Santana, LF
  • Nieves-Cintrón, M
  • Navedo, MF
  • et al.
Abstract

Calcium (Ca2+) plays a central role in excitation, contraction, transcription, and proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca2+ concentration ([Ca2+]i) is crucial for proper physiological VSM function. Studies over the last several decades have revealed that VSMs express a variety of Ca2+-permeable channels that orchestrate a dynamic, yet finely tuned regulation of [Ca2+]i. In this review, we discuss the major Ca2+-permeable channels expressed in VSM and their contribution to vascular physiology and pathology.

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