Skip to main content
Ligand-Controlled Diastereoselective 1,3-Dipolar Cycloadditions of Azomethine Ylides with Methacrylonitrile.
- Author(s): Walton, Mary C;
- Yang, Yun-Fang;
- Hong, Xin;
- Houk, KN;
- Overman, Larry E
- et al.
Published Web Locationhttps://doi.org/10.1021/acs.orglett.5b03171
Copper-catalyzed reactions of glycine ester arylimines and methacrylonitrile provide selective access to either the endo or exo pyrrolidine cycloadducts. DFT calculations have elucidated the origins of ligand-controlled diastereoselectivity.
For improved accessibility of PDF content, download the file to your device.