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Ligand-Controlled Diastereoselective 1,3-Dipolar Cycloadditions of Azomethine Ylides with Methacrylonitrile.

  • Author(s): Walton, Mary C
  • Yang, Yun-Fang
  • Hong, Xin
  • Houk, KN
  • Overman, Larry E
  • et al.

Copper-catalyzed reactions of glycine ester arylimines and methacrylonitrile provide selective access to either the endo or exo pyrrolidine cycloadducts. DFT calculations have elucidated the origins of ligand-controlled diastereoselectivity.

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