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The role of CuI in the siloxane-mediated Pd-catalyzed cross-coupling reactions of aryl iodides with aryl lithium reagents
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https://doi.org/10.1016/j.cclet.2020.05.009Abstract
Experiments indicate that a catalytic amount of CuI plays an important role in the siloxane-mediated Pd-catalyzed cross-coupling reactions with the direct use of organolithium reagents. Addition of organolithium to the siloxane transfer agent generates an organosilicon intermediate. DFT calculations indicate that CuI initially accelerates the Si-Pd(II) transmetalation of the organosilicon intermediate by the formation of CuI2 -. Subsequently, CuI2 - works as a shuttle between the Si-Cu(I) and Cu(I)-Pd(II) transmetalation processes.
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