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Dynamic study of irradiated artificial skin using OCT

  • Author(s): Jung, WG;
  • Kao, B;
  • Kelly, KM;
  • Ding, Z;
  • Nelson, JS;
  • Chen, Z
  • et al.

Published Web Location

https://doi.org/10.1117/12.479043Creative Commons 'BY' version 4.0 license
Abstract

We report a novel application of optical coherence tomography (OCT), to monitor post-laser irradiation collagen injury in skin model. An artificial skin model (RAFT) which closely approximates human skin, was irradiated with a Perovskite laser (λ = 1341 nm). We investigated dynamic changes in a RAFT after laser irradiation through OCT and compared the results to those of histology. OCT images clearly delineated areas of post-irradiation collagen injury and allowed non-invasive monitoring of the wound healing process. Histology was correlated well with OCT images. OCT has advantages because it is non-invasive and allows serial monitoring at the same site over time. Our study showed that OCT may be a useful tool for determination of optimal parameters for non-ablative laser skin rejuvenation (NALSR) using different devices.

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