Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment
- Author(s): Baraban, Scott
- Dinday, MT
- Hortopan, GA
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3891590?pdf=render
Dravet syndrome is a catastrophic pediatric epilepsy with severe intellectual disability, impaired social development and persistent drug-resistant seizures. One of its primary monogenic causes are mutations in Na v 1.1 (SCN1A), a voltage-gated sodium chan