Skip to main content
eScholarship
Open Access Publications from the University of California

Aptavalve-gated mesoporous carbon nanospheres image cellular mucin and provide on-demand targeted drug delivery

  • Author(s): Li, C
  • Qian, M
  • Wang, S
  • Jiang, H
  • Du, Y
  • Wang, J
  • Lu, W
  • Murthy, N
  • Huang, R
  • et al.

Published Web Location

http://doi.org/10.7150/thno.18692
No data is associated with this publication.
Abstract

© Ivyspring International Publisher. In this report, we present a mesoporous carbon nanosphere that can target drugs to tumors and image tumor biomarkers. A single-strand DNA (P0aptamer) aptavalve was capped on the surface of doxorubicin-loaded oxide mesoporous carbon nanospheres (Dox-OMCN-P0) through p-p stacking for real-time imaging-guided on-demand targeting drug delivery. The Dox-OMCN-P0could not only realize the detection of MUC1 tumor marker with a wide linear range (0.1 - 10.6 μmol/L) and a low detection limit (17.5 nmol) based on different apparatuses, but also achieve in-situ targeting imaging of cellular MUC1 concentration in vitro and in vivo via "off-on" fluorescence biosensing. Much attractively, as a real-time feedback of the diagnostic/imaging outcomes, Dox-OMCN-P0accomplished the on-demand targeting drug delivery in quantitative response to MUC1. Controllable chemotherapy with sustained release and pH-sensitiveness, together with the potential photothermal therapy, were also clearly demonstrated. This is a simple but advanced platform, which could well achieve the real-time switchable imaging of cellular mucin for targeting cancer therapy.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item