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Hit-to-Lead Development of the Chamigrane Endoperoxide Merulin A for the Treatment of African Sleeping Sickness

  • Author(s): McKerrow, James;
  • Navarro, G;
  • Chokpaiboon, S;
  • de, G;
  • Bray, WM;
  • Nisam, SC;
  • McKerrow, JH;
  • Pudhom, K;
  • Linington, RG
  • et al.

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Background: Human African trypanosomiasis (HAT) is an infectious disease with a large global health burden occurring primarily in Central and Eastern Africa. Most current treatments have poor blood brain barrier (BBB) penetration, which prevent them from t

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