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Kinesin-5: A Team Is Just the Sum of Its Parts.

  • Author(s): Hueschen, Christina L
  • Long, Alexandra F
  • Dumont, Sophie
  • et al.
Abstract

How the cell builds a spindle remains an open question. In this issue of Developmental Cell, Shimamoto, Forth, and Kapoor (2015) show that kinesin-5 motor ensembles can exert sliding forces that scale with microtubule overlap length. This behavior could allow microtubule architecture-dependent modulation of force and contribute to spindle self-organization.

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