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Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil
- Penetra, Stephanie LS;
- da Silva, Michele FB;
- Resende, Paola;
- Pina-Costa, Anielle;
- Santos, Heloisa FP;
- Guaraldo, Lusiele;
- Calvet, Guilherme A;
- Ogrzewalska, Maria;
- Arantes, Ighor;
- Zukeram, Ketiuce;
- de Araújo, Mia F;
- Lima, Ana Beatriz Machado;
- Lopes, Renata Serrano;
- Lira-Silva, Larissa R;
- Moraes, Isabella V;
- Wakimoto, Mayumi D;
- Fuller, Trevon L;
- Gabaglia, Claudia Raja;
- Espíndola, Otávio M;
- Bonaldo, Myrna C;
- Daniel-Ribeiro, Cláudio Tadeu;
- Whitworth, Jimmy;
- Smith, Chris;
- Nielsen-Saines, Karin;
- Pauvolid-Correa, Alex;
- Siqueira, Marilda M;
- Brasil, Patricia
- et al.
Published Web Location
https://doi.org/10.1016/j.ijid.2021.10.048Abstract
We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33. Infections were confirmed by whole-genome sequencing and corroborated by the detection of neutralizing antibodies in convalescent serum samples. Considering the permanent exposure of this healthcare worker to SARS-CoV-2, the waning immunity after the first infection, the low efficacy of the inactivated vaccine at preventing COVID-19, the immune escape of the Gamma variant (VOC), and the burden of post-COVID syndrome, this individual would have benefited from an additional dose of a heterologous vaccine.
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