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Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase
Published Web Location
http://europepmc.org/articles/PMC4171511?pdf=renderNo data is associated with this publication.
Abstract
Background: Over 70% of low-grade gliomas carry a heterozygous R132H mutation in the gene coding for isocitrate dehydrogenase 1 (IDH1). This confers the enzyme with the novel ability to convert a-ketoglutarate to 2-hydroxyglutarate, ultimately leading to t
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