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Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase

  • Author(s): Ronen, Sabrina
  • Pieper, Russell
  • Phillips, Joanna
  • Izquierdo-Garcia, JL
  • Cai, LM
  • Chaumeil, MM
  • Eriksson, P
  • Robinson, AE
  • Pieper, RO
  • Phillips, JJ
  • Ronen, SM
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4171511?pdf=render
No data is associated with this publication.
Abstract

Background: Over 70% of low-grade gliomas carry a heterozygous R132H mutation in the gene coding for isocitrate dehydrogenase 1 (IDH1). This confers the enzyme with the novel ability to convert a-ketoglutarate to 2-hydroxyglutarate, ultimately leading to t

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