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Open Access Publications from the University of California

Applications of CRISPR-Cas Enzymes in Cancer Therapeutics and Detection.

  • Author(s): Huang, Chun-Hao
  • Lee, Ko-Chuan
  • Doudna, Jennifer A
  • et al.

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Cancer is a complex disease caused by combinations of cellular genetic alterations and heterogeneous microenvironments. The use of the robust and programmable CRISPR-Cas systems has greatly improved genome editing for precision cancer modeling and enabled multiplexed genetic manipulation for cancer treatment and mutation detection. In this review, we outline the current CRISPR-Cas toolkit, and discuss the promises and hurdles in translating this revolutionary technology into effective and safe clinical applications for cancer treatment and diagnosis.

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