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Open Access Publications from the University of California

Prophylactic treatment with VT-1161 protects immunosuppressed mice from rhizopus arrhizus var. Arrhizus infection

  • Author(s): Gebremariam, T
  • Alkhazraji, S
  • Lin, L
  • Wiederhold, NP
  • Garvey, EP
  • Hoekstra, WJ
  • Schotzinger, RJ
  • Patterson, TF
  • Filler, SG
  • Ibrahim, AS
  • et al.

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Copyright © 2017 American Society for Microbiology. All Rights Reserved. We compared prophylactic or continuous therapy with the investiga-tional drug VT-1161 to that with posaconazole in treating murine mucormycosis due to Rhizopus arrhizus var. arrhizus. In the prophylaxis studies, only VT-1161 resulted in improved survival and lowered tissue fungal burden of immunosuppressed infected mice. In the continuous therapy, VT-1161 outperformed posaconazole in prolonging mouse survival time despite its comparable effect in lowering tissue fungal burden. These results support the further development of VT-1161 against mucormycosis.

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