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Atrial Fibrillation is Associated With Greater Risk of Dementia in Older Veterans
Published Web Location
https://doi.org/10.1016/j.jagp.2021.02.038Abstract
Objectives
To examine the association of atrial fibrillation (AF) with incident dementia in older veterans and the effect of anticoagulation on that association.Methods
Around 407,871 veterans aged ≥55 years receiving care from US Veterans Health Administration between August 2003 and September 2015 were included in our retrospective study. AF and incident dementia were determined according to ICD-9-CM codes. Logistic regressions with veterans grouped into high-dimensional propensity scores deciles were used, and a mediation analysis was employed to examine the extent of cardio/cerebrovascular diseases that may also account for that association.Results
AF was associated with greater dementia risk (odds ratio = 1.14; 95% confidence interval 1.07-1.22), partially mediated by cardio/cerebrovascular disease. Among veterans with AF taking anticoagulants, the risk of dementia was 44% higher (odds ratio =1.44; 95% CI 1.27-1.63) compared to those without anticoagulants, likely related to AF severity.Conclusion
Our findings underscore the importance of considering cognitive function in the management of AF patients.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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