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Excessive Vitamin A Consumption and Fractures: How Much is Too Much?

Abstract

In 2001 the Food and Nutrition Board (FNB) of the Institute of Medicine, after reviewing the available literature, set the tolerable upper intake level of vitamin A at 3,000 g/day (1). While setting the upper intake level, the FNB chose not to factor into their decision several conflicting studies linking excessive vitamin A consumption with fractures. Since the vitamin A review, however, further studies have continued to solidify the relationship between high vitamin A intake and fracture risk. One such study found that ingestion of a daily amount of vitamin A significantly less than the tolerable upper intake level was associated with doubling the likelihood of a fracture (2). Many other studies like this one draw the same conclusions suggesting prudence in vitamin A consumption and the necessity of lowering the currently accepted tolerable upper intake level.

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