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The intricate dance of post-translational modifications in the rhythm of life.

  • Author(s): Hirano, Arisa
  • Fu, Ying-Hui
  • Ptáček, Louis J
  • et al.

Published Web Location

https://doi.org/10.1038/nsmb.3326
Abstract

Endogenous biological rhythms with approximately 24-h periodicity are generated by the circadian clock, in which clock genes coordinate with one another and form a transcriptional-translational negative feedback loop. The precision of the circadian clock is further regulated by multiple post-translational modifications (PTMs), including phosphorylation, ubiquitination, acetylation and SUMOylation. Here, we review current understanding of the regulatory mechanisms of the core clock proteins by PTMs in the mammalian circadian clock.

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