Skip to main content
Download PDF
- Main
Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease
- Peloso, Gina M;
- van der Lee, Sven J;
- Project, International Genomics of Alzheimer's;
- Sims, R;
- van der Lee, SJ;
- Naj, AC;
- Bellenguez, C;
- Badarinarayan, N;
- Jakobsdottir, J;
- Kunkle, BW;
- Boland, A;
- Raybould, R;
- Bis, JC;
- Martin, ER;
- Grenier‐Boley, B;
- Heilmann‐Heimbach, S;
- Chouraki, V;
- Kuzma, AB;
- Sleegers, K;
- Vronskaya, M;
- Ruiz, A;
- Graham, RR;
- Olaso, R;
- Hoffmann, P;
- Grove, ML;
- Vardarajan, BN;
- Hiltunen, M;
- Nöthen, MM;
- White, CC;
- Hamilton‐Nelson, KL;
- Epelbaum, J;
- Maier, W;
- Choi, SH;
- Beecham, GW;
- Dulary, C;
- Herms, S;
- Smith, AV;
- Funk, CC;
- Derbois;
- Forstner, AJ;
- Ahmad, S;
- Li, H;
- Bacq, D;
- Harold, D;
- Satizabal, CL;
- Valladares, O;
- Squassina, A;
- Thomas, R;
- Brody, JA;
- Qu, L;
- Sánchez‐Juan, P;
- Morgan, T;
- Wolters, FJ;
- Zhao, Y;
- Garcia, FS;
- Denning, N;
- Fornage, M;
- Malamon, J;
- Naranjo, MCD;
- Majounie, E;
- Mosley, TH;
- Dombroski, B;
- Wallon, D;
- Lupton, MK;
- Dupuis, J;
- Whitehead, P;
- Fratiglioni, L;
- Medway, C;
- Jian, X;
- Mukherjee, S;
- Keller, L;
- Brown, K;
- Lin, H;
- Cantwell, LB;
- Panza, F;
- McGuinness, B;
- Moreno‐Grau, S;
- Burgess, JD;
- Solfrizzi, V;
- Proitsi, P;
- Adams, HH;
- Allen, M;
- Seripa, D;
- Pastor, P;
- Cupples, LA;
- Price, ND;
- Hannequin, D;
- Frank‐García, A;
- Levy, D;
- Chakrabarty, P;
- Caffarra, P;
- Giegling, I;
- Beiser, AS;
- Giedraitis, V;
- Hampel, H;
- Garcia, ME;
- Wang, X;
- Lannfelt, L;
- Mecocci, P;
- Eiriksdottir, G;
- Crane, PK;
- Pasquier, F;
- Boccardi, V;
- Henández, I;
- Barber, RC;
- Scherer, M;
- Tarraga, L;
- Adams, PM;
- Leber, M;
- Chen, Y;
- Albert, MS;
- Riedel‐Heller, S;
- Emilsson, V;
- Beekly, D;
- Braae, A;
- Schmidt, R;
- Blacker, D;
- Masullo, C;
- Schmidt, H;
- Doody, RS;
- Spalletta, G;
- Longstreth, WT;
- Fairchild, TJ;
- Bossù, P;
- Lopez, OL;
- Frosch, MP;
- Sacchinelli, E;
- Ghetti, B;
- Yang, Q;
- Huebinger, RM;
- Jessen, F;
- Li, S;
- Kamboh, MI;
- Morris, J;
- Sotolongo‐Grau, O;
- Katz, MJ;
- Corcoran, C;
- Dunstan, M;
- Braddel, A;
- Thomas, C;
- Meggy, A;
- Marshall, R;
- Gerrish, A;
- Chapman, J;
- Aguilar, M;
- Taylor, S;
- Hill, M;
- Fairén, MD;
- Hodges, A;
- Vellas, B;
- Soininen, H;
- Kloszewska, I;
- Daniilidou, M;
- Uphill, J;
- Patel, Y;
- Hughes, JT;
- Lord, J;
- Turton, J;
- Hartmann, AM;
- Cecchetti, R;
- Fenoglio, C;
- Serpente, M;
- Arcaro, M;
- Caltagirone, C;
- Orfei, MD;
- Ciaramella, A;
- Pichler, S;
- Mayhaus, M;
- Gu, W;
- Lleó, A;
- Fortea, J;
- Blesa, R;
- Barber, IS;
- Brookes, K;
- Cupidi, C;
- Maletta, RG;
- Carrell, D;
- Sorbi, S;
- Moebus, S;
- Urbano, M;
- Pilotto, A;
- Kornhuber, J;
- Bosco, P;
- Todd, S;
- Craig, D;
- Johnston, J;
- Gill, M;
- Lawlor, B;
- Lynch, A;
- Fox, NC;
- Hardy, J;
- Consortium, ARUK;
- Albin, RL;
- Apostolova, LG;
- Arnold, SE;
- Asthana, S;
- Atwood, CS;
- Baldwin, CT;
- Barnes, LL;
- Barral, S;
- Beach, TG;
- Becker, JT;
- Bigio, EH;
- Bird, TD;
- Boeve, BF;
- Bowen, JD;
- Boxer, A;
- Burke, JR;
- Burns, JM;
- Buxbaum, JD;
- Cairns, NJ;
- Cao, C;
- Carlson, CS;
- Carlsson, CM;
- Carney, RM;
- Carrasquillo, MM;
- Carroll, SL;
- Diaz, CC;
- Chui, HC;
- Clark, DG;
- Cribbs, DH;
- Crocco, EA;
- DeCarli, C;
- Dick, M;
- Duara, R;
- Evans, DA;
- Faber, KM;
- Fallon, KB;
- Fardo, DW;
- Farlow, MR;
- Ferris, S;
- Foroud, TM;
- Galasko, DR;
- Gearing, M;
- Geschwind, DH;
- Gilbert, JR;
- Graff‐Radford, NR;
- Green, RC;
- Growdon, JH;
- Hamilton, RL;
- Harrell, LE;
- Honig, LS;
- Huentelman, MJ;
- Hulette, CM;
- Hyman, BT;
- Jarvik, GP;
- Abner, E;
- Jin, LW;
- Jun, G;
- Karydas, A;
- Kaye, JA;
- Kim, R;
- Kowall, NW;
- Kramer, JH;
- LaFerla, FM;
- Lah, JJ;
- Leverenz, JB;
- Levey, AI;
- Li, G;
- Lieberman, AP;
- Lunetta, KL;
- Lyketsos, CG;
- Marson, DC;
- Martiniuk, F;
- Mash, DC;
- Masliah, E;
- McCormick, WC;
- McCurry, SM;
- McDavid, AN;
- McKee, AC;
- Mesulam, M;
- Miller, BL;
- Miller, CA;
- Miller, JW;
- Morris, JC;
- Murrell, JR;
- Myers, AJ;
- O'Bryant, S;
- Olichney, JM;
- Pankratz, VS;
- Parisi, JE;
- Paulson, HL;
- Perry, W;
- Peskind, E;
- Pierce, A;
- Poon, WW;
- Potter, H;
- Quinn, JF;
- Raj, A;
- Raskind, M;
- Reisberg, B;
- Reitz, C;
- Ringman, JM;
- Roberson, ED;
- Rogaeva, E;
- Rosen, HJ;
- Rosenberg, RN;
- Sager, MA;
- Saykin, AJ;
- Schneider, JA;
- Schneider, LS;
- Seeley, WW;
- Smith, AG;
- Sonnen, JA;
- Spina, S;
- Stern, RA;
- Swerdlow, RH;
- Tanzi, RE;
- Thornton‐Wells, TA;
- Trojanowski, JQ;
- Troncoso, JC;
- Van Deerlin, VM;
- Van Eldik, LJ;
- Vinters, HV;
- Vonsattel, JP;
- Weintraub, S;
- Welsh‐Bohmer, KA;
- Wilhelmsen, KC;
- Williamson, J;
- Wingo, TS;
- Woltjer, RL;
- Wright, CB;
- Yu, CE;
- Yu, L;
- Garzia, F;
- Golamaully, F;
- Septier, G;
- Engelborghs, S;
- Vandenberghe, R;
- De Deyn, PP;
- Fernadez, CM;
- Benito, YA;
- Thonberg, H;
- Forsell, C;
- Lilius, L;
- Kinhult‐Stählbom, A;
- Kilander, L;
- Brundin, R;
- Concari, L;
- Helisalmi, S;
- Koivisto, AM;
- Haapasalo, A;
- Dermecourt, V;
- Fievet, N;
- Hanon, O;
- Dufouil, C;
- Brice, A;
- Ritchie, K;
- Dubois, B;
- Himali, JJ;
- Keene, CD;
- Tschanz, J;
- Fitzpatrick, AL;
- Kukull, WA;
- Norton, M;
- Aspelund, T;
- Larson, EB;
- Munger, R;
- Rotter, JI;
- Lipton, RB;
- Bullido, MJ;
- Hofman, A;
- Montine, TJ;
- Coto, E;
- Boerwinkle, E;
- Petersen, RC;
- Alvarez, V;
- Rivadeneira, F;
- Reiman, EM;
- Gallo, M;
- O'Donnell, CJ;
- Reisch, JS;
- Bruni, AC;
- Royall, DR;
- Dichgans, M;
- Sano, M;
- Galimberti, D;
- St George‐Hyslop, P;
- Scarpini, E;
- Tsuang, DW;
- Mancuso, M;
- Bonuccelli, U;
- Winslow, AR;
- Daniele, A;
- Wu, CK;
- GERAD/PERADES, CHARGE;
- Peters, O;
- Nacmias, B;
- Riemenschneider, M;
- Heun, R;
- Brayne, C;
- Rubinsztein, DC;
- Bras, J;
- Guerreiro, R;
- Al‐Chalabi, A;
- Shaw, CE;
- Collinge, J;
- Mann, D;
- Tsolaki, M;
- Clarimón, J;
- Sussams, R;
- Lovestone, S;
- O'Donovan, MC;
- Owen, MJ;
- Behrens, TW;
- Mead, S;
- Goate, AM;
- Uitterlinden, AG;
- Holmes, C;
- Cruchaga, C;
- Ingelsson, M;
- Bennett, DA;
- Powell, J;
- Golde, TE;
- Graff, C;
- De Jager, PL;
- Morgan, K;
- Ertekin‐Taner, N;
- Combarros, O;
- Psaty, BM;
- Passmore, P;
- Younkin, SG;
- Berr, C;
- Gudnason, V;
- Rujescu, D;
- Dickson, DW;
- Dartigues, JF;
- DeStefano, AL;
- Ortega‐Cubero, S;
- Hakonarson, H;
- Campion, D;
- Boada, M;
- Kauwe, JK;
- Farrer, LA;
- Van Broeckhoven, C;
- Ikram, MA;
- Jones, L;
- Haines, JL;
- Tzourio, C;
- Launer, LJ;
- Escott‐Price, V;
- Mayeux, R;
- Deleuze, JF;
- Amin, N;
- Holmans, PA;
- Pericak‐Vance, MA;
- Amouyel, P;
- van Duijn, CM;
- Ramirez, A;
- Wang, LS;
- Lambert, JC;
- Seshadri, S;
- Williams, J;
- Schellenberg, GD;
- Destefano, Anita L;
- Seshardi, Sudha
- et al.
Published Web Location
https://doi.org/10.1016/j.dadm.2018.08.008Abstract
Introduction
There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL-C. We aimed to assess AD risk by genetically predicted HDL-C.Methods
Ten single nucleotide polymorphisms within the CETP locus predicting HDL-C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR-Egger.Results
Based on 10 single nucleotide polymorphisms distinctly predicting HDL-C in the CETP locus, we found that HDL-C was not associated with risk of AD (P > .7).Discussion
Our study does not support the role of HDL-C on risk of AD through HDL-C altered by CETP. This study does not rule out other mechanisms by which HDL-C affects risk of AD.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
For improved accessibility of PDF content, download the file to your device.
Enter the password to open this PDF file:
File name:
-
File size:
-
Title:
-
Author:
-
Subject:
-
Keywords:
-
Creation Date:
-
Modification Date:
-
Creator:
-
PDF Producer:
-
PDF Version:
-
Page Count:
-
Page Size:
-
Fast Web View:
-
Preparing document for printing…
0%