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Open Access Publications from the University of California

Paradoxical response to sedative/hypnotics in patients with Self-injurious behavior and stereotypy

  • Author(s): Sandman, Curt A
  • Barron, Jennifer L
  • et al.

Paradoxical response to sedative medication has been reported previously among patients with Self-injurious (SIB) and Stereotypic (ST) Behavior (Barron and Sandman, 1983, 1985). The prevalence of this marker was examined in 648 consecutive developmentally delayed patients tested in the EEG laboratory. Several analyses compared response to sedative/hypnotics, assessment of the EEG, and behavioral profiles from the most recent annual comprehensive behavioral/medical evaluation (CDER). The presence of SIB and ST were significantly related to paradoxical response. The EEG was not related to paradoxical response, but had fewer epileptic foci in frequent or severe SIB and/or ST. © 1992 Plenum Publishing Corporation.

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