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Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
- Conde, Lucia;
- Halperin, Eran;
- Akers, Nicholas K;
- Brown, Kevin M;
- Smedby, Karin E;
- Rothman, Nathaniel;
- Nieters, Alexandra;
- Slager, Susan L;
- Brooks-Wilson, Angela;
- Agana, Luz;
- Riby, Jacques;
- Liu, Jianjun;
- Adami, Hans-Olov;
- Darabi, Hatef;
- Hjalgrim, Henrik;
- Low, Hui-Qi;
- Humphreys, Keith;
- Melbye, Mads;
- Chang, Ellen T;
- Glimelius, Bengt;
- Cozen, Wendy;
- Davis, Scott;
- Hartge, Patricia;
- Morton, Lindsay M;
- Schenk, Maryjean;
- Wang, Sophia S;
- Armstrong, Bruce;
- Kricker, Anne;
- Milliken, Sam;
- Purdue, Mark P;
- Vajdic, Claire M;
- Boyle, Peter;
- Lan, Qing;
- Zahm, Shelia H;
- Zhang, Yawei;
- Zheng, Tongzhang;
- Becker, Nikolaus;
- Benavente, Yolanda;
- Boffetta, Paolo;
- Brennan, Paul;
- Butterbach, Katja;
- Cocco, Pierluigi;
- Foretova, Lenka;
- Maynadié, Marc;
- de Sanjosé, Silvia;
- Staines, Anthony;
- Spinelli, John J;
- Achenbach, Sara J;
- Call, Timothy G;
- Camp, Nicola J;
- Glenn, Martha;
- Caporaso, Neil E;
- Cerhan, James R;
- Cunningham, Julie M;
- Goldin, Lynn R;
- Hanson, Curtis A;
- Kay, Neil E;
- Lanasa, Mark C;
- Leis, Jose F;
- Marti, Gerald E;
- Rabe, Kari G;
- Rassenti, Laura Z;
- Spector, Logan G;
- Strom, Sara S;
- Vachon, Celine M;
- Weinberg, J Brice;
- Holly, Elizabeth A;
- Chanock, Stephen;
- Smith, Martyn T;
- Bracci, Paige M;
- Skibola, Christine F
- et al.
Published Web Location
https://doi.org/10.1038/ng.626Abstract
To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).
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