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Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate
- Lin, Yin C;
- Benner, Christopher;
- Mansson, Robert;
- Heinz, Sven;
- Miyazaki, Kazuko;
- Miyazaki, Masaki;
- Chandra, Vivek;
- Bossen, Claudia;
- Glass, Christopher K;
- Murre, Cornelis
Published Web Location
https://doi.org/10.1038/ni.2432Abstract
Lineage development is accompanied by specification of gene expression. Murre and colleagues show that during B cell development, many genes relocate in the nucleus, driven by chromatin-looping interactions with transcription factors.
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