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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka.
- Grifoni, Alba;
- Weiskopf, Daniela;
- Lindestam Arlehamn, Cecilia S;
- Angelo, Michael;
- Leary, Shay;
- Sidney, John;
- Frazier, April;
- Phillips, Elizabeth;
- Mallal, Simon;
- Mack, Steven J;
- Tippalagama, Rashmi;
- Goonewardana, Suraj;
- Premawansa, Sunil;
- Premawansa, Gayani;
- Wijewickrama, Ananda;
- De Silva, Aruna D;
- Sette, Alessandro
- et al.
Published Web Location
https://doi.org/10.1016/j.humimm.2017.12.007Abstract
DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proportions were not detected at any locus. Several alleles were found in >30% of individuals, including the class II alleles DPB1 * 04:01, DPB1 * 02:01, DQB1 * 06:01 and DRB1 * 07:01, and the class I alleles A * 33:03 and A * 24:02. Genotype data will be available in the Allele Frequencies Net Database.
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