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Association of anti-tuberculosis drug concentrations in hair and treatment outcomes in MDR- and XDR-TB.

  • Author(s): Metcalfe, John;
  • Bacchetti, Peter;
  • Gerona, Roy;
  • Esmail, Ali;
  • Dheda, Keertan;
  • Gandhi, Monica
  • et al.
Abstract

Therapeutic drug monitoring for drug-resistant tuberculosis (TB) is likely to improve treatment outcomes. While assessments of plasma drug levels can explain pharmacokinetic variability among trial participants, these measures require phlebotomy and a cold chain, and are generally not repeated frequently enough to characterise drug exposure over time. Using a novel multi-analyte assay, we found evidence that higher anti-TB drug concentrations in hair, a non-biohazardous and noninvasively collected biomatrix, predict extensively-drug resistant-TB clinical outcomes in a high-burden setting.

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