The Self-Assembling Process and Applications in Tissue Engineering.
- Author(s): Lee, Jennifer K;
- Link, Jarrett M;
- Hu, Jerry CY;
- Athanasiou, Kyriacos A
- et al.
Published Web Locationhttps://doi.org/10.1101/cshperspect.a025668
Tissue engineering strives to create neotissues capable of restoring function. Scaffold-free technologies have emerged that can recapitulate native tissue function without the use of an exogenous scaffold. This review will survey, in particular, the self-assembling and self-organization processes as scaffold-free techniques. Characteristics and benefits of each process are described, and key examples of tissues created using these scaffold-free processes are examined to provide guidance for future tissue-engineering developments. We aim to explore the potential of self-assembly and self-organization scaffold-free approaches, detailing the recent progress in the in vitro tissue engineering of biomimetic tissues with these methods toward generating functional tissue replacements.