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PI3Kγ is a molecular switch that controls immune suppression
- Kaneda, Megan M;
- Messer, Karen S;
- Ralainirina, Natacha;
- Li, Hongying;
- Leem, Christopher J;
- Gorjestani, Sara;
- Woo, Gyunghwi;
- Nguyen, Abraham V;
- Figueiredo, Camila C;
- Foubert, Philippe;
- Schmid, Michael C;
- Pink, Melissa;
- Winkler, David G;
- Rausch, Matthew;
- Palombella, Vito J;
- Kutok, Jeffery;
- McGovern, Karen;
- Frazer, Kelly A;
- Wu, Xuefeng;
- Karin, Michael;
- Sasik, Roman;
- Cohen, Ezra EW;
- Varner, Judith A
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479689/No data is associated with this publication.
Abstract
Modulation of PI3Kγ activity regulates macrophage polarization during inflammation and cancer, whilst combining PI3Kγ inhibition with immune checkpoint inhibitors leads to synergistic tumour-inhibitory effects.
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