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Friction at the BAR Leads to Membrane Breakup.
Published Web Locationhttps://doi.org/10.1016/j.cell.2017.06.027
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A long-standing question in cell biology is how endocytic vesicles and tubules detach from the plasma membrane in the absence of constriction by dynamin. In this issue of Cell, Simunovic et al. describe an elegant biophysical model in which friction between lipids and BAR-domain proteins drives the scission of elongating membrane tubules.
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