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Parallel Parkin: Cdc20 Takes a New Partner
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https://doi.org/10.1016/j.molcel.2015.09.015Abstract
CDC20 and CDH1 are well-established substrate receptors for the Anaphase Promoting Complex/Cyclosome (APC/C). In this issue of Molecular Cell, Lee et al. (2015) show that these adaptors can also target cell cycle proteins for destruction through a second ubiquitin ligase, Parkin.
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