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A low-cost open-source SNP genotyping platform for association mapping applications.

  • Author(s): Macdonald, Stuart J;
  • Pastinen, Tomi;
  • Genissel, Anne;
  • Cornforth, Theodore W;
  • Long, Anthony D
  • et al.
Abstract

Association mapping aimed at identifying DNA polymorphisms that contribute to variation in complex traits entails genotyping a large number of single-nucleotide polymorphisms (SNPs) in a very large panel of individuals. Few technologies, however, provide inexpensive high-throughput genotyping. Here, we present an efficient approach developed specifically for genotyping large fixed panels of diploid individuals. The cost-effective, open-source nature of our methodology may make it particularly attractive to those working in nonmodel systems.

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