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Synthesis and Molecular Properties of Nerve Agent Reactivator HLö-7 Dimethanesulfonate.
Published Web Location
https://doi.org/10.1021/acsmedchemlett.9b00021Abstract
The threat of a deliberate release of chemical nerve agents has underscored the need to continually improve field effective treatments for these types of poisonings. The oxime containing HLö-7 is a potential second-generation therapeutic reactivator. A synthetic process for HLö-7 is detailed with improvements to the DIBAL reduction and ion exchange steps. HLö-7 was visualized for the first time within the active site of human acetylcholinesterase and its relative ex vivo potency confirmed against various nerve agents using a phrenic nerve hemidiaphragm assay.
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