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Association of Culturable-Virus Detection and Household Transmission of SARS-CoV-2, California and Tennessee, 2020-2022.
- Deyoe, Jessica E;
- Kelly, J Daniel;
- Grijalva, Carlos G;
- Bonenfant, Gaston;
- Lu, Scott;
- Anglin, Khamal;
- Garcia-Knight, Miguel;
- Pineda-Ramirez, Jesus;
- Hagen, Melissa Briggs;
- Saydah, Sharon;
- Abedi, Glen R;
- Goldberg, Sarah A;
- Tassetto, Michel;
- Zhang, Amethyst;
- Donohue, Kevin C;
- Davidson, Michelle C;
- Sanchez, Ruth Diaz;
- Djomaleu, Manuella;
- Mathur, Sujata;
- Shak, Joshua R;
- Deeks, Steven G;
- Peluso, Michael J;
- Chiu, Charles Y;
- Zhu, Yuwei;
- Halasa, Natasha B;
- Chappell, James D;
- Mellis, Alexandra;
- Reed, Carrie;
- Andino, Raul;
- Martin, Jeffrey N;
- Zhou, Bin;
- Talbot, H Keipp;
- Midgley, Claire M;
- Rolfes, Melissa A
- et al.
Published Web Location
https://doi.org/10.1093/infdis/jiad018Abstract
From 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) household transmission studies (enrolling April 2020 to January 2022) with rapid enrollment and specimen collection for 14 days, 61% (43/70) of primary cases had culturable virus detected ≥6 days post-onset. Risk of secondary infection among household contacts tended to be greater when primary cases had culturable virus detected after onset. Regardless of duration of culturable virus, most secondary infections (70%, 28/40) had serial intervals <6 days, suggesting early transmission. These data examine viral culture as a proxy for infectiousness, reaffirm the need for rapid control measures after infection, and highlight the potential for prolonged infectiousness (≥6 days) in many individuals.
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