UC Irvine

Objective

To explore the utility of dual-energy spectral computed tomography (CT) in the differential diagnosis of focal organizing pneumonia (FOP) and solitary bronchioloalveolar carcinoma (S-BAC).

Materials and methods

The institutional review board approved this study and waived the requirement for informed consent. It is a retrospective study. A total of 105 patients (62 with FOP and 43 with S-BAC) enrolled and all patients have contrast enhanced spectral CT including the arterial phase (AP) and venous phase (VP). During AP and VP, CT_{40 keV}, CT_{70 keV}, and CT_{100 keV} values, iodine concentration (IC), water concentration (WC), and effective atomic number (Zeff) were measured on monochromatic and iodine-based material decomposition images, and the slope of the spectral curve (λ_Hu) was calculated. The two-sample t-test was used to compare quantitative parameters, and receiver operating characteristic (ROC) curves were generated to calculate diagnostic efficacies.

Results

For AP, CT_{40 keV} and CT_{70 keV} values, IC, WC, Zeff, λ_{70 keV}, and λ_{100 keV} measurements, there were significantly higher in patients with S-BAC than in those with FOP (P < 0.05). However, these quantitative parameters of VP were significantly lower in patients with S-BAC than in those with FOP (P < 0.05). ROC curve analysis revealed that the combination of all quantitative parameters in AP and VP provided the best diagnostic performance in distinguishing S-BAC from FOP (area under the ROC curve, 93.1%; sensitivity, 95.3%; specificity, 77.4%).

Conclusions

Dual-energy spectral CT has the potential to identify S-BAC and FOP.