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Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia

  • Author(s): Muschen, Markus
  • Gang, EJ
  • Hsieh, YT
  • Pham, J
  • Zhao, Y
  • Nguyen, C
  • Huantes, S
  • Park, E
  • Naing, K
  • Klemm, L
  • Swaminathan, S
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3994178?pdf=render
No data is associated with this publication.
Abstract

Drug resistance in acute lymphoblastic leukemia (ALL) remains a major problem warranting new treatment strategies. Wnt/catenin signaling is critical for the self-renewal of normal hematopoietic progenitor cells. Deregulated Wnt signaling is evident in chro

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