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Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits

  • Author(s): Dubal, Dena
  • Mucke, Lennart
  • Harris, JA
  • Koyama, A
  • Maeda, S
  • Ho, K
  • Devidze, N
  • Dubal, DB
  • Yu, GQ
  • Masliah, E
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3454317?pdf=render
No data is associated with this publication.
Abstract

Accumulation of hyperphosphorylated tau in the entorhinal cortex (EC) is one of the earliest pathological hallmarks in patients with Alzheimer's disease (AD). It can occur before significant Aβ deposition and appears to "spread" into anatomically connected

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