Synthetic biology for microbial production of lipid-based biofuels
- Author(s): d'Espaux, L
- Mendez-Perez, D
- Li, R
- Keasling, JD
- et al.
Published Web Locationhttp://www.sciencedirect.com/science/article/pii/S1367593115001064
© 2015. The risks of maintaining current CO2emission trends have led to interest in producing biofuels using engineered microbes. Microbial biofuels reduce emissions because CO2produced by fuel combustion is offset by CO2captured by growing biomass, which is later used as feedstock for biofuel fermentation. Hydrocarbons found in petroleum fuels share striking similarity with biological lipids. Here we review synthetic metabolic pathways based on fatty acid and isoprenoid metabolism to produce alkanes and other molecules suitable as biofuels. We further discuss engineering strategies to optimize engineered biosynthetic routes, as well as the potential of synthetic biology for sustainable manufacturing.
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