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Functional Effects of let-7g Expression in Colon Cancer Metastasis.

  • Author(s): Chang, Che-Mai
  • Wong, Henry Sung-Ching
  • Huang, Chien-Yu
  • Hsu, Wen-Li
  • Maio, Zhi-Feng
  • Chiu, Siou-Jin
  • Tsai, Yao-Ting
  • Chen, Ben-Kuen
  • Wan, Yu-Jui Yvonne
  • Wang, Jaw-Yuan
  • Chang, Wei-Chiao
  • et al.
Abstract

MicroRNA regulation is crucial for gene expression and cell functions. It has been linked to tumorigenesis, development and metastasis in colorectal cancer (CRC). Recently, the let-7 family has been identified as a tumor suppressor in different types of cancers. However, the function of the let-7 family in CRC metastasis has not been fully investigated. Here, we focused on analyzing the role of let-7g in CRC. The Cancer Genome Atlas (TCGA) genomic datasets of CRC and detailed data from a Taiwanese CRC cohort were applied to study the expression pattern of let-7g. In addition, in vitro as well as in vivo studies have been performed to uncover the effects of let-7g on CRC. We found that the expression of let-7g was significantly lower in CRC specimens. Our results further supported the inhibitory effects of let-7g on CRC cell migration, invasion and extracellular calcium influx through store-operated calcium channels. We report a critical role for let-7g in the pathogenesis of CRC and suggest let-7g as a potential therapeutic target for CRC treatment.

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