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Sequence of bronchoalveolar lavage and histopathologic findings in rat lungs early in inhalation asbestos exposure

  • Author(s): Smith, CM
  • Batcher, S
  • Catanzaro, A
  • Abraham, JL
  • Phalen, R
  • et al.
Abstract

To assess the early cellular inflammatory response of the lungs, 7 rats per group were exposed nose-only to 13 mg/m3of chrysotile asbestos, 7 h/day for 2, 4, or 6 wk. Lung histopathology and bronchoalveolar lavage (BAL) were analyzed. In exposed animals, dose-related bronchiolitis and fibrosis were found that were not seen in control rats (p < 0.001). In exposed rats, total BAL cells were increased six- to sevenfold over matched controls, and more cells were retrieved with longer exposure (p < 0.001). In the BAL, counts of macrophages, lymphocytes, and polymorphonuclear cells (PMNs) were each elevated in the exposed rats (each p < 0.001). PMNs seen histologically and in the BAL may be related to the time period examined. PMNs and lymphocytes observed throughout this 6-wk study support the idea that these cells may have an important role in the early events of asbestos lung injury. © 1987 Taylor & Francis Group, LLC.

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