Skip to main content
eScholarship
Open Access Publications from the University of California

UC Berkeley

UC Berkeley Previously Published Works bannerUC Berkeley

Data Management and Network Architecture Effect on Performance Variability in Direct Attenuation Correction via Deep Learning for Cardiac SPECT: A Feasibility Study

Abstract

Attenuation correction (AC) is important for accurate interpretation of SPECT myocardial perfusion imaging (MPI). However, it is challenging to perform AC in dedicated cardiac systems not equipped with a transmission imaging capability. Previously, we demonstrated the feasibility of generating attenuation-corrected SPECT images using a deep learning technique (SPECTDL) directly from non-corrected images (SPECTNC). However, we observed performance variability across patients which is an important factor for clinical translation of the technique. In this study, we investigate the feasibility of overcoming the performance variability across patients for the direct AC in SPECT MPI by proposing to develop an advanced network and a data management strategy. To investigate, we compared the accuracy of the SPECTDL for the conventional U-Net and Wasserstein cycle GAN (WCycleGAN) networks. To manage the training data, clustering was applied to a representation of data in the lower-dimensional space, and the training data were chosen based on the similarity of data in this space. Quantitative analysis demonstrated that DL model with an advanced network improves the global performance for the AC task with the limited data. However, the regional results were not improved. The proposed data management strategy demonstrated that the clustered training has potential benefit for effective training.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View