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EGFR ligands dictate tumour suppression
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https://doi.org/10.1038/s41556-022-00967-zAbstract
Amplification of EGFR occurs frequently in glioblastoma. Canonically, EGFR is an oncogene with a major role in cancer pathogenesis. A new study posits a tumor suppressive role of EGFR in EGFR-amplified glioblastoma, regulated by ligand abundance. Increased EGFR ligand in EGFR-amplified glioblastoma suppresses invasion by upregulation of BIN3, inhibiting activation of Rho GTPases.
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