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The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
- Fernandes-Alnemri, Teresa;
- Yu, Je-Wook;
- Juliana, Christine;
- Solorzano, Leobaldo;
- Kang, Seokwon;
- Wu, Jianghong;
- Datta, Pinaki;
- McCormick, Margaret;
- Huang, Lan;
- McDermott, Erin;
- Eisenlohr, Laurence;
- Landel, Carlisle P;
- Alnemri, Emad S
Published Web Location
https://doi.org/10.1038/ni.1859Abstract
The AIM2 inflammasome induces maturation of the proinflammatory cytokines IL-1β and IL-18. Using AIM2-deficient mice, Fitzgerald and colleagues and Alnemri and colleagues show that the AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
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