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Lower Urine Tenofovir Concentrations Among Individuals Taking Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate: Implications for Point-of-Care Testing.

  • Author(s): Johnson, Kelly A
  • Niu, Xin
  • Glidden, David V
  • Castillo-Mancilla, Jose R
  • Yager, Jenna
  • MaWhinney, Samantha
  • Morrow, Mary
  • Okochi, Hideaki
  • Cressey, Tim R
  • Drain, Paul K
  • Gandhi, Monica
  • Anderson, Peter L
  • Spinelli, Matthew A
  • et al.
Abstract

From directly observed therapy studies, urine tenofovir (TFV) levels were 74% lower when taking tenofovir alafenamide (TAF) vs tenofovir disoproxil fumarate. Urine TFV remains quantifiable across a range of TAF adherence patterns, but a separate point-of-care lateral flow immunoassay with a lower TFV threshold will be needed to support TAF adherence monitoring.

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