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Activation of RhoA, Smad2, c-Src, PKC-βII/δ and JNK in atopic dermatitis.

  • Author(s): Lu, Jianyun
  • Yin, Rong
  • Fu, Zhibing
  • Lee, Veronica M
  • Nelson, John Stuart
  • Tan, Wenbin
  • et al.

Published Web Location

https://doi.org/10.1111/ajd.12801
Abstract

Atopic dermatitis is a multifactorial skin disease characterised by chronic and relapsing inflammation whose pathogenesis is incompletely understood. We found that the expression of TGFβR1 and the activation of SMAD2, RhoA, JNK, PKC-βII/δ and c-Src were upregulated in the infiltrated inflammatory cells, fibroblasts and vasculatures in the dermis and epidermis. In addition, increases in the expression of TGFβR1 and phosphorylation levels of JNK and c-Src were positively correlated with the inflammatory progression of atopic dermatitis severity.

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