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Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.
- van Erp, Theo GM;
- Walton, Esther;
- Hibar, Derrek P;
- Schmaal, Lianne;
- Jiang, Wenhao;
- Glahn, David C;
- Pearlson, Godfrey D;
- Yao, Nailin;
- Fukunaga, Masaki;
- Hashimoto, Ryota;
- Okada, Naohiro;
- Yamamori, Hidenaga;
- Bustillo, Juan R;
- Clark, Vincent P;
- Agartz, Ingrid;
- Mueller, Bryon A;
- Cahn, Wiepke;
- de Zwarte, Sonja MC;
- Hulshoff Pol, Hilleke E;
- Kahn, René S;
- Ophoff, Roel A;
- van Haren, Neeltje EM;
- Andreassen, Ole A;
- Dale, Anders M;
- Doan, Nhat Trung;
- Gurholt, Tiril P;
- Hartberg, Cecilie B;
- Haukvik, Unn K;
- Jørgensen, Kjetil N;
- Lagerberg, Trine V;
- Melle, Ingrid;
- Westlye, Lars T;
- Gruber, Oliver;
- Kraemer, Bernd;
- Richter, Anja;
- Zilles, David;
- Calhoun, Vince D;
- Crespo-Facorro, Benedicto;
- Roiz-Santiañez, Roberto;
- Tordesillas-Gutiérrez, Diana;
- Loughland, Carmel;
- Carr, Vaughan J;
- Catts, Stanley;
- Cropley, Vanessa L;
- Fullerton, Janice M;
- Green, Melissa J;
- Henskens, Frans A;
- Jablensky, Assen;
- Lenroot, Rhoshel K;
- Mowry, Bryan J;
- Michie, Patricia T;
- Pantelis, Christos;
- Quidé, Yann;
- Schall, Ulrich;
- Scott, Rodney J;
- Cairns, Murray J;
- Seal, Marc;
- Tooney, Paul A;
- Rasser, Paul E;
- Cooper, Gavin;
- Shannon Weickert, Cynthia;
- Weickert, Thomas W;
- Morris, Derek W;
- Hong, Elliot;
- Kochunov, Peter;
- Beard, Lauren M;
- Gur, Raquel E;
- Gur, Ruben C;
- Satterthwaite, Theodore D;
- Wolf, Daniel H;
- Belger, Aysenil;
- Brown, Gregory G;
- Ford, Judith M;
- Macciardi, Fabio;
- Mathalon, Daniel H;
- O'Leary, Daniel S;
- Potkin, Steven G;
- Preda, Adrian;
- Voyvodic, James;
- Lim, Kelvin O;
- McEwen, Sarah;
- Yang, Fude;
- Tan, Yunlong;
- Tan, Shuping;
- Wang, Zhiren;
- Fan, Fengmei;
- Chen, Jingxu;
- Xiang, Hong;
- Tang, Shiyou;
- Guo, Hua;
- Wan, Ping;
- Wei, Dong;
- Bockholt, Henry J;
- Ehrlich, Stefan;
- Wolthusen, Rick PF;
- King, Margaret D;
- Shoemaker, Jody M;
- Sponheim, Scott R;
- De Haan, Lieuwe;
- Koenders, Laura;
- Machielsen, Marise W;
- van Amelsvoort, Therese;
- Veltman, Dick J;
- Assogna, Francesca;
- Banaj, Nerisa;
- de Rossi, Pietro;
- Iorio, Mariangela;
- Piras, Fabrizio;
- Spalletta, Gianfranco;
- McKenna, Peter J;
- Pomarol-Clotet, Edith;
- Salvador, Raymond;
- Corvin, Aiden;
- Donohoe, Gary;
- Kelly, Sinead;
- Whelan, Christopher D;
- Dickie, Erin W;
- Rotenberg, David;
- Voineskos, Aristotle N;
- Ciufolini, Simone;
- Radua, Joaquim;
- Dazzan, Paola;
- Murray, Robin;
- Reis Marques, Tiago;
- Simmons, Andrew;
- Borgwardt, Stefan;
- Egloff, Laura;
- Harrisberger, Fabienne;
- Riecher-Rössler, Anita;
- Smieskova, Renata;
- Alpert, Kathryn I;
- Wang, Lei;
- Jönsson, Erik G;
- Koops, Sanne;
- Sommer, Iris EC;
- Bertolino, Alessandro;
- Bonvino, Aurora;
- Di Giorgio, Annabella;
- Neilson, Emma;
- Mayer, Andrew R;
- Stephen, Julia M;
- Kwon, Jun Soo;
- Yun, Je-Yeon;
- Cannon, Dara M;
- McDonald, Colm;
- Lebedeva, Irina;
- Tomyshev, Alexander S;
- Akhadov, Tolibjohn;
- Kaleda, Vasily;
- Fatouros-Bergman, Helena;
- Flyckt, Lena;
- Karolinska Schizophrenia Project;
- Busatto, Geraldo F;
- Rosa, Pedro GP;
- Serpa, Mauricio H;
- Zanetti, Marcus V;
- Hoschl, Cyril;
- Skoch, Antonin;
- Spaniel, Filip;
- Tomecek, David;
- Hagenaars, Saskia P;
- McIntosh, Andrew M;
- Whalley, Heather C;
- Lawrie, Stephen M;
- Knöchel, Christian;
- Oertel-Knöchel, Viola;
- Stäblein, Michael;
- Howells, Fleur M;
- Stein, Dan J;
- Temmingh, Henk S;
- Uhlmann, Anne;
- Lopez-Jaramillo, Carlos;
- Dima, Danai;
- McMahon, Agnes;
- Faskowitz, Joshua I;
- Gutman, Boris A;
- Jahanshad, Neda;
- Thompson, Paul M;
- Turner, Jessica A
Published Web Location
https://doi.org/10.1016/j.biopsych.2018.04.023Abstract
Background
The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group.Methods
The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11-78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10-87 years; 53% male) assessed with standardized methods at 39 centers worldwide.Results
Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen's d = -0.530/-0.516) and smaller surface area (left/right hemisphere: Cohen's d = -0.251/-0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness and positive correlations with age at onset.Conclusions
The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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