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Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway
- Prud’homme, Mathilde;
- Coutrot, Maxime;
- Michel, Thibault;
- Boutin, Louis;
- Genest, Magali;
- Poirier, Françoise;
- Launay, Jean-Marie;
- Kane, Bocar;
- Kinugasa, Satoshi;
- Prakoura, Niki;
- Vandermeersch, Sophie;
- Cohen-Solal, Alain;
- Delcayre, Claude;
- Samuel, Jane-Lise;
- Mehta, Ravindra;
- Gayat, Etienne;
- Mebazaa, Alexandre;
- Chadjichristos, Christos E;
- Legrand, Matthieu
- et al.
Published Web Location
https://doi.org/10.1016/j.jacbts.2019.06.005Abstract
Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway.
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