- Main
Microglial Gi-dependent dynamics regulate brain network hyperexcitability
- Merlini, Mario;
- Rafalski, Victoria A;
- Ma, Keran;
- Kim, Keun-Young;
- Bushong, Eric A;
- Rios Coronado, Pamela E;
- Yan, Zhaoqi;
- Mendiola, Andrew S;
- Sozmen, Elif G;
- Ryu, Jae Kyu;
- Haberl, Matthias G;
- Madany, Matthew;
- Sampson, Daniel Naranjo;
- Petersen, Mark A;
- Bardehle, Sophia;
- Tognatta, Reshmi;
- Dean, Terry;
- Acevedo, Rosa Meza;
- Cabriga, Belinda;
- Thomas, Reuben;
- Coughlin, Shaun R;
- Ellisman, Mark H;
- Palop, Jorge J;
- Akassoglou, Katerina
- et al.
Published Web Location
https://doi.org/10.1038/s41593-020-00756-7Abstract
Microglial surveillance is a key feature of brain physiology and disease. Here, we found that Gi-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating MgPTX mice to genetically inhibit Gi in microglia, we show that sustained reduction of microglia brain surveillance and directed process motility induced spontaneous seizures and increased hypersynchrony after physiologically evoked neuronal activity in awake adult mice. Thus, Gi-dependent microglia dynamics may prevent hyperexcitability in neurological diseases.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
Enter the password to open this PDF file:
-
-
-
-
-
-
-
-
-
-
-
-
-
-