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Open Access Publications from the University of California

Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type i modular polyketide synthases: Opportunities and challenges

  • Author(s): Yuzawa, S
  • Keasling, JD
  • Katz, L
  • et al.

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© 2017 Japan Antibiotics Research Association All rights reserved 0021-8820/17. Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. We have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could have applications as fuels or industrial chemicals.

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