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Clotting activity of polyphosphate-functionalized silica Nanoparticles

  • Author(s): Kudela, D
  • Smith, SA
  • May-Masnou, A
  • Braun, GB
  • Pallaoro, A
  • Nguyen, CK
  • Chuong, TT
  • Nownes, S
  • Allen, R
  • Parker, NR
  • Rashidi, HH
  • Morrissey, JH
  • Stucky, GD
  • et al.
Abstract

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings.

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