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Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models
- Svensson, Robert U;
- Parker, Seth J;
- Eichner, Lillian J;
- Kolar, Matthew J;
- Wallace, Martina;
- Brun, Sonja N;
- Lombardo, Portia S;
- Van Nostrand, Jeanine L;
- Hutchins, Amanda;
- Vera, Lilliana;
- Gerken, Laurie;
- Greenwood, Jeremy;
- Bhat, Sathesh;
- Harriman, Geraldine;
- Westlin, William F;
- Harwood, H James;
- Saghatelian, Alan;
- Kapeller, Rosana;
- Metallo, Christian M;
- Shaw, Reuben J
Published Web Location
https://doi.org/10.1038/nm.4181Abstract
An allosteric inhibitor of acetyl-CoA carboxylase reveals a metabolic liability of non-small-cell lung cancer and slows tumor growth alone and in combination with chemotherapy in mouse models.
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