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Home-based walking exercise in peripheral artery disease: 12-month follow-up of the GOALS randomized trial.

  • Author(s): McDermott, Mary M
  • Guralnik, Jack M
  • Criqui, Michael H
  • Ferrucci, Luigi
  • Zhao, Lihui
  • Liu, Kiang
  • Domanchuk, Kathryn
  • Spring, Bonnie
  • Tian, Lu
  • Kibbe, Melina
  • Liao, Yihua
  • Lloyd Jones, Donald
  • Rejeski, W Jack
  • et al.
Abstract

We studied whether a 6-month group-mediated cognitive behavioral (GMCB) intervention for peripheral artery disease (PAD) participants, which promoted home-based walking exercise, improved 6-minute walk and other outcomes at 12-month follow-up, 6 months after completing the intervention, compared to a control group.We randomized PAD participants to a GMCB intervention or a control group. During phase I (months 1 to 6), the intervention used group support and self-regulatory skills during weekly on-site meetings to help participants adhere to home-based exercise. The control group received weekly on-site lectures on topics unrelated to exercise. Primary outcomes were measured at the end of phase I. During phase II (months 7 to 12), each group received telephone contact. Compared to controls, participants randomized to the intervention increased their 6-minute walk distance from baseline to 12-month follow-up, (from 355.4 to 381.9 m in the intervention versus 353.1 to 345.6 m in the control group; mean difference=+34.1 m; 95% confidence interval [CI]=+14.6, +53.5; P<0.001) and their Walking Impairment Questionnaire (WIQ) speed score (from 36.1 to 46.5 in the intervention group versus 34.9 to 36.5 in the control group; mean difference =+8.8; 95% CI=+1.6, +16.1; P=0.018). Change in the WIQ distance score was not different between the 2 groups at 12-month follow-up (P=0.139).A weekly on-site GMCB intervention that promoted home-based walking exercise intervention for people with PAD demonstrated continued benefit at 12-month follow-up, 6 months after the GMCB intervention was completed.ClinicalTrials.gov. Unique identifier: NCT00693940.

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